Sphingosine Kinase 1 and Sphingosine-1-Phosphate Signaling in Colorectal Cancer
نویسندگان
چکیده
منابع مشابه
Sphingosine Kinase 1 and Sphingosine-1-Phosphate Signaling in Colorectal Cancer
Sphingosine kinase 1 (Sphk1) is a highly conserved lipid kinase that phosphorylates sphingosine to form sphingosine-1-phosphate (S1P). Growing studies have demonstrated that Sphk1 is overexpressed in various types of solid cancers and can be induced by growth factors, cytokines, and carcinogens, leading to the increase of S1P production. Subsequently, the increased Sphk1/S1P facilitates cancer ...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2017
ISSN: 1422-0067
DOI: 10.3390/ijms18102109